x2iezn.8xlarge is AWS's memory-optimized EC2 size at 32 vCPU and 1024 GiB. In the name, "x" is the extra-memory line, "2" is the generation, "iezn" marks Intel processors, extended capacity, a higher clock and enhanced networking and "8xlarge" is the size within the x2iezn family. It runs on Intel Xeon Platinum 8252 at 4.5 GHz, and AWS introduced it in January 2022. AWS has since shipped x8i; x8i.8xlarge is the direct replacement at this size, scoring 761,452 CoreMark/s against this instance's 646,726 — roughly 18% more throughput for the same vCPU count. The closest Spot shape is mh.vs1.2xlarge at 16 vCPU, so this instance maps to 8 of them — 128 vCPU and 1024 GiB across the fleet, $6.67/hr on AWS in US East (N. Virginia), from $0.168/hr on Rackspace Spot. Spot delivers compute as managed Kubernetes, so a node pool of that size is the native shape of the answer rather than a workaround — provided the workload scales horizontally.
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x2iezn.8xlarge gives you 32 vCPU and 1,024 GiB in a single machine. The largest comparable Spot node, mh.vs1.2xlarge, is 16 vCPU and 128 GiB, so the equivalent here is 8 nodes rather than one.
Spot runs as managed Kubernetes, so a 8-node pool is the normal way to run things rather than a workaround. If your workload already sits behind a load balancer, a queue or a scheduler, it spreads across them without changes. If it needs all 32 cores and 1,024 GiB in one process, it does not.