x2iezn.4xlarge is AWS's memory-optimized EC2 size at 16 vCPU and 512 GiB. In the name, "x" is the extra-memory line, "2" is the generation, "iezn" marks Intel processors, extended capacity, a higher clock and enhanced networking and "4xlarge" is the size within the x2iezn family. It runs on Intel Xeon Platinum 8252 at 4.5 GHz, and AWS introduced it in January 2022. AWS has since shipped x8i; x8i.4xlarge is the direct replacement at this size, scoring 384,631 CoreMark/s against this instance's 319,696 — roughly 20% more throughput for the same vCPU count. The closest Spot shape is mh.vs1.2xlarge at 16 vCPU, so this instance maps to 4 of them — 64 vCPU and 512 GiB across the fleet, $3.34/hr on AWS in US East (N. Virginia), from $0.084/hr on Rackspace Spot. Spot delivers compute as managed Kubernetes, so a node pool of that size is the native shape of the answer rather than a workaround — provided the workload scales horizontally.
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x2iezn.4xlarge gives you 16 vCPU and 512 GiB in a single machine. The largest comparable Spot node, mh.vs1.2xlarge, is 16 vCPU and 128 GiB, so the equivalent here is 4 nodes rather than one.
Spot runs as managed Kubernetes, so a 4-node pool is the normal way to run things rather than a workaround. If your workload already sits behind a load balancer, a queue or a scheduler, it spreads across them without changes. If it needs all 16 cores and 512 GiB in one process, it does not.