The r6g.4xlarge is a memory-optimized AWS EC2 instance: 16 vCPU and 128 GiB of memory, 8.00 GiB per vCPU. In the name, "r" stands for RAM, "6" is the generation, "g" marks AWS Graviton (ARM) processors and "4xlarge" is the size within the r6g family. It runs on AWS Graviton2 Processor at 2.5 GHz, and AWS introduced it in June 2020. AWS has since shipped r7g, r8g and r9g; r7g.4xlarge is the direct replacement at this size, scoring 411,073 CoreMark/s against this instance's 312,134 — roughly 32% more throughput for the same vCPU count. Rackspace Spot's mh.vs1.2xlarge is a like-for-like substitute at 16 vCPU and 128 GiB, $0.806/hr on AWS in US East (N. Virginia), from $0.021/hr on Rackspace Spot.
Match qualityx86 substitution
r6g.4xlarge is Graviton (arm64). Rackspace Spot does not have arm64 servers, so mh.vs1.2xlarge is an x86_64 substitute with similar specs.
You will need x86 builds of your container images. Most software rebuilds without changes, but anything with compiled native code needs a real rebuild rather than a retag. Speed per core also differs between the two chips, so it is worth testing before deciding how many nodes to run.