The m5dn.16xlarge pairs 64 vCPU with 256 GiB of RAM, the 4.00 GiB-per-vCPU ratio that marks a general-purpose instance. In the name, "m" is the general-purpose line, "5" is the generation, "dn" marks local NVMe storage and enhanced networking and "16xlarge" is the size within the m5dn family. It runs on Intel Xeon Platinum 8259 (Cascade Lake) at 3.1 GHz, and AWS introduced it in October 2019. AWS has since shipped m6i, m7i, m8i and m9g; m6i.16xlarge is the direct replacement at this size. Spot's node ladder tops out below this size, so m5dn.16xlarge becomes 4 × gp.vs1.2xlarge (64 vCPU, 256 GiB combined), $4.35/hr on AWS in US East (N. Virginia), from $0.164/hr on Rackspace Spot. Spot delivers compute as managed Kubernetes, so a node pool of that size is the native shape of the answer rather than a workaround — provided the workload scales horizontally.
| Region | AWS on-demand | AWS Spot | 1-yr Reserved | 3-yr Reserved | Rackspace Spot | You save |
|---|---|---|---|---|---|---|
| US East, N. Virginia | $4.352 | $1.191 | $2.742 | $1.692 | $0.164 | $4.188 savings |
| US Central, Chicago | no AWS region | $0.164 | ||||
| US Central, Dallas | no AWS region | $0.204 | ||||
| Hong Kong | $0.044 | |||||
| Sydney, Australia | $0.644 | |||||
| London, UK | $0.884 | |||||
| US West, San Jose | $0.604 | |||||
| US Central, Dallas 2 | no AWS region | $0.004 | ||||
| US East, N. Virginia 2 | $4.352 | $1.191 | $2.742 | $1.692 | $0.604 | $3.748 savings |