The m4.16xlarge is a general-purpose AWS EC2 instance: 64 vCPU and 256 GiB of memory, 4.00 GiB per vCPU. In the name, "m" is the general-purpose line, "4" is the generation and "16xlarge" is the size within the m4 family. It runs on Intel Xeon E5-2686 v4 (Broadwell) at 2.4 GHz, and AWS introduced it in September 2016. AWS has since shipped m5, m6i, m7i and m8i; m5.16xlarge is the direct replacement at this size. No single Spot node covers 64 vCPU and 256 GiB, so the equivalent is a fleet: 4 × gp.vs1.2xlarge, 64 vCPU and 256 GiB in total, about 95% below the US East (N. Virginia) on-demand rate. Spot delivers compute as managed Kubernetes, so a node pool of that size is the native shape of the answer rather than a workaround — provided the workload scales horizontally.
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m4.16xlarge gives you 64 vCPU and 256 GiB in a single machine. The largest comparable Spot node, gp.vs1.2xlarge, is 16 vCPU and 64 GiB, so the equivalent here is 4 nodes rather than one.
Spot runs as managed Kubernetes, so a 4-node pool is the normal way to run things rather than a workaround. If your workload already sits behind a load balancer, a queue or a scheduler, it spreads across them without changes. If it needs all 64 cores and 256 GiB in one process, it does not.
