The m4.10xlarge pairs 40 vCPU with 160 GiB of RAM, the 4.00 GiB-per-vCPU ratio that marks a general-purpose instance. In the name, "m" is the general-purpose line, "4" is the generation and "10xlarge" is the size within the m4 family. It runs on Intel Xeon E5-2676 v3 (Haswell) at 2.4 GHz, and AWS introduced it in June 2015. AWS has since shipped m5, m6i, m7i and m8i. Spot's node ladder tops out below this size, so m4.10xlarge becomes 3 × gp.vs1.2xlarge (48 vCPU, 192 GiB combined), about 94% below the US East (N. Virginia) on-demand rate. Spot delivers compute as managed Kubernetes, so a node pool of that size is the native shape of the answer rather than a workaround — provided the workload scales horizontally.
Match qualityScale-out match
m4.10xlarge gives you 40 vCPU and 160 GiB in a single machine. The largest comparable Spot node, gp.vs1.2xlarge, is 16 vCPU and 64 GiB, so the equivalent here is 3 nodes rather than one.
Spot runs as managed Kubernetes, so a 3-node pool is the normal way to run things rather than a workaround. If your workload already sits behind a load balancer, a queue or a scheduler, it spreads across them without changes. If it needs all 40 cores and 160 GiB in one process, it does not.